Excited-state Proton Transfer Study in Potential Hyaluronan-surfactant Drug Nanocarriers
نویسندگان
چکیده
Hyaluronan is a biopolymer suitable as a targeting unit in drug delivery systems according to affinity of hyaluronan to CD-44 receptor of cancer cells. We suppose that hyaluronan, when interacts with cationic surfactant, influences hydration of Stern layer of CTAB which affects fluorescence properties of 1-naphthol. We study excited state proton transfer of 1-naphthol in aqueous solution and in hyaluronan-cetyltrimethylammonium bromide (CTAB) system by steady-state and time-resolved fluorescence techniques. Neutral naphthol form shows change in fluorescence intensity of aqueous micelle solution around reported critical micelle concentration (~1 mM) which suggests solubilisation of 1-naphthol in micelles. Steadystate study of neutral naphthol in hyaluronan-CTAB system shows similar behaviour as in aqueous CTAB system. On the contrary the time-resolved study of 1-naphthol shows change in fluorescence lifetimes of neutral and anion naphthol forms with increasing CTAB concentration. The change in fluorescence lifetimes of anion naphthol before critical micelle concentration suggests formation of hyaluronan-CTAB aggregates before critical micelle concentration is reached. Kinetic study of excited state proton transfer showed that hyaluronan influenced proton transfer kinetics of 1-naphthol and suggested that hyaluronan influenced Stern layer of micelle.
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